Eld.gg Diablo 4 Items: Tips for Completing the Quest Efficiently
How to Unlock Keepers of Diablo 4 Items the Glen

To trigger Keepers of the Glen, you'll need to:

1. Complete the following prior quests:

Bearing the Weight of Ghosts
The Truths That Lie Within (gain Horadric Knowledge from Nightmare Dungeons)

2. Reach Tier 3 of your Reputation Track for the Season 9 Horadric system.

Once these are done, the quest should automatically appear in your journal, though you may need to manually track it from your quest log.

Keepers of the Glen Objectives

Here's the step-by-step breakdown of what you'll need to do:

1. Speak to Bryona in Cerrigar

She will brief you on the next steps, tied directly to your growing relationship with the Horadrim.

2. Use a Nightmare Sigil to Find a Strongroom

You must activate a Nightmare Dungeon Sigil that contains a Horadric Strongroom.
Look for keywords or icons on the sigil description that mention Strongrooms.
If you don't have one, run Nightmare Dungeons until one drops that guarantees a Strongroom.

3. Retrieve a Blood Relic from the Strongroom

Once inside the Strongroom, your goal is to:

Navigate through shrines and altars.
Kill as many enemies as possible before the timer runs out.
Fight the boss Pyroclast, who replaces Agony from the last Strongroom.
Loot the Blood Relic from the Strongroom chest.

Tips for Completing the Quest Efficiently

Clear the Entire Dungeon: While technically you don't need to finish the full Nightmare Dungeon, completing it gives you a new Sigil and extra Diablo 4 Items. You might as well do both while you're there.
Look for the Strongroom Early: It can spawn before or cheap Diablo 4 materials after the final boss. Find it first so you know what your pacing looks like.